Function and Biology Details
Reaction catalysed:
Hydrolysis of proteins with broad specificity for peptide bonds, but preference for an amino acid bearing a large hydrophobic side chain at the P2 position. Does not accept Val in P1'.
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Papain and Cysteine proteinase inhibitor (preferred)
PDBe Complex ID:
PDB-CPX-133548 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Papain
Molecule details ›
Chains: A, C
Length: 212 amino acids
Theoretical weight: 23.5 KDa
Source organism: Carica papaya
UniProt:
Structure domains: Cysteine proteinases
Length: 212 amino acids
Theoretical weight: 23.5 KDa
Source organism: Carica papaya
UniProt:
- Canonical:
P00784 (Residues: 134-345; Coverage: 65%)
Structure domains: Cysteine proteinases
Cysteine proteinase inhibitor
Molecule details ›
Chains: B, D
Length: 91 amino acids
Theoretical weight: 10.2 KDa
Source organism: Colocasia esculenta
Expression system: Escherichia coli
UniProt:
Sequence domains: Aspartic acid proteinase inhibitor
Structure domains: Nuclear Transport Factor 2; Chain: A,
Length: 91 amino acids
Theoretical weight: 10.2 KDa
Source organism: Colocasia esculenta
Expression system: Escherichia coli
UniProt:
- Canonical: Q8L5J8 (Residues: 2-92; Coverage: 44%)
Sequence domains: Aspartic acid proteinase inhibitor
Structure domains: Nuclear Transport Factor 2; Chain: A,
