3ima Summary


Complex strcuture of tarocystatin and papain

A publication describing this structure is not available. The depositing authors are Chu, M.H.search; Liu, K.L.search; Yeh, K.W.search; Cheng, Y.S.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.03 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Papain and Cysteine proteinase inhibitor.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Papain Not available
Carica papayasearch < 90% 212 100%
C Papain P00784 (134-345) (PAPA1_CARPA)search Carica papayasearch 98% 212 100%
B Cysteine proteinase inhibitor Q8L5J8 (2-92) (Q8L5J8_COLES)search Colocasia esculentasearch < 90% 91 93%
D Cysteine proteinase inhibitor Not available
Colocasia esculentasearch < 90% 91 93%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q8L5J8 (2 - 92) Cysteine proteinase inhibitor Colocasia esculenta
P00784 (134 - 345) Papain Carica papaya

Chain Structural classification (CATH) Sequence family (Pfam)
A, C (P00784) Cysteine proteinasessearch PF00112: Papain family cysteine proteasesearch
B, D Nuclear Transport Factor 2; Chain: A,search Cystatin domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, C (P00784) cysteine-type peptidase activitysearch proteolysissearch
B, D (Q8L5J8) cysteine-type endopeptidase inhibitor activitysearch

Chain InterPro annotation
A, C Cysteine peptidase, cysteine active sitesearch Peptidase C1A, papain C-terminalsearch Peptidase C1Asearch Cysteine peptidase, histidine active sitesearch Cysteine peptidase, asparagine active sitesearch
B, D Proteinase inhibitor I25, cystatinsearch Proteinase inhibitor I25, cystatin, conserved sitesearch Proteinase inhibitor I25, cystatin, conserved regionsearch Cystatinsearch