3ii5 Summary

pdbe.org/3ii5
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The Complex of wild-type B-RAF with Pyrazolo pyrimidine inhibitor

The structure was published by Berger, D.M., Torres, N., Dutia, M., et al., Frommer, E., Wojciechowicz, D., and Mallon, R., in 2009 in a paper entitled "Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.79 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of B-Raf proto-oncogene serine/threonine-protein kinase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A B-Raf proto-oncogene serine/threonine-protein kinase P15056 (432-726) (BRAF_HUMAN)search Homo sapienssearch < 90% 306 85%
B B-Raf proto-oncogene serine/threonine-protein kinase P15056 (432-726) (BRAF_HUMAN)search Homo sapienssearch < 90% 306 85%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P15056 (432 - 726) B-Raf proto-oncogene serine/threonine-protein kinase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch
Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch