› 3ihz

X-ray diffraction
1.67Å resolution

Crystal structure of the FK506 binding domain of Plasmodium vivax FKBP35 in complex with FK506

Released:
DOI: 10.2210/pdb3ihz/pdb
PDB entry 3ihz coloured by chain, front view.
PDB entry 3ihz coloured by chain, side view.
PDB entry 3ihz coloured by chain, top view.
Source organism: Plasmodium vivax
Primary publication:
NMR and crystallographic structures of the FK506 binding domain of human malarial parasite Plasmodium vivax FKBP35.
Alag R, Qureshi IA, Bharatham N, Shin J, Lescar J, Yoon HS
Protein Sci 19 1577-86 (2010)
PMID: 20572013

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-107693 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
peptidylprolyl isomerase Chains: A, B
Molecule details ›
Chains: A, B
Length: 126 amino acids
Theoretical weight: 13.97 KDa
Source organism: Plasmodium vivax
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A5K8X6 (Residues: 1-126; Coverage: 42%)
Gene name: PVX_101260
Sequence domains: FKBP-type peptidyl-prolyl cis-trans isomerase
Structure domains: Chitinase A; domain 3

Ligands and Environments

1 bound ligand:
Ligand FK5 1 x FK5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21
Unit cell:
a: 55.9Å b: 40.9Å c: 56.9Å
α: 90° β: 109.5° γ: 90°
R-values:
R R work R free
0.19 0.188 0.233
Expression system: Escherichia coli BL21(DE3)

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Citations

1 review citation

From crystal to compound: structure-based antimalarial drug discovery.
Drinkwater et al. (2014)
10 other articles

5 mentions without citation

Structural insights into Plasmodium PPIases.
Rajan et al. (2022)
4 more