3iec Summary

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Helicobacter pylori CagA Inhibits PAR1/MARK Family Kinases by Mimicking Host Substrates

The structure was published by Nesic, D., Miller, M.C., Quinkert, Z.T., Stein, M., Chait, B.T., and Stebbins, C.E., in 2010 in a paper entitled "Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Serine/threonine-protein kinase MARK2 and Cytotoxicity-associated immunodominant antigen.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Serine/threonine-protein kinase MARK2 Q7KZI7 (49-363) (MARK2_HUMAN)search Homo sapienssearch < 90% 319 98%
B Serine/threonine-protein kinase MARK2 Q7KZI7 (49-363) (MARK2_HUMAN)search Homo sapienssearch < 90% 319 98%
C Serine/threonine-protein kinase MARK2 Q7KZI7 (49-363) (MARK2_HUMAN)search Homo sapienssearch < 90% 319 98%
D Serine/threonine-protein kinase MARK2 Q7KZI7 (49-363) (MARK2_HUMAN)search Homo sapienssearch < 90% 319 98%
E Cytotoxicity-associated immunodominant antigen P55980 (885-1005) (CAGA_HELPY)search Helicobacter pylori 26695search < 90% 125 11%
F Cytotoxicity-associated immunodominant antigen P55980 (885-1005) (CAGA_HELPY)search Helicobacter pylori 26695search < 90% 125 11%
G Cytotoxicity-associated immunodominant antigen P55980 (885-1005) (CAGA_HELPY)search Helicobacter pylori 26695search < 90% 125 11%
H Cytotoxicity-associated immunodominant antigen P55980 (885-1005) (CAGA_HELPY)search Helicobacter pylori 26695search < 90% 125 11%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q7KZI7 (49 - 363) Serine/threonine-protein kinase MARK2 Homo sapiens
P55980 (885 - 1005) Cytotoxicity-associated immunodominant antigen Helicobacter pylori

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D Transferase(Phosphotransferase) domain 1search, DNA helicase RuvA subunit, C-terminal domainsearch Protein kinase domainsearch
E, F, G, H CagA exotoxinsearch

Chain ID Biological process (GO) Molecular function (GO)
A, B, C, D (Q7KZI7) protein phosphorylationsearch ATP bindingsearch protein serine/threonine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A, B, C, D Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryotesearch Protein kinase, ATP binding sitesearch
E, F, G, H CagA exotoxinsearch