3id8 Summary


Ternary complex of human pancreatic glucokinase crystallized with activator, glucose and AMP-PNP

The structure was published by Petit, P., Antoine, M., Ferry, G., et al., Gluais, L., Vincentelli, R., and Vuillard, L., in 2011 in a paper entitled "The active conformation of human glucokinase is not altered by allosteric activators" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glucokinase. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 470 residues which is 98% of the natural sequence. Out of 470 residues 450 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucokinase P35557 (12-465) (HXK4_HUMAN)search Homo sapienssearch 97% 470 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (12 - 465) Glucokinase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P35557) Hexokinase; domain 1search, Nucleotidyltransferase; domain 5search PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P35557) phosphotransferase activity, alcohol group as acceptorsearch ATP bindingsearch hexokinase activitysearch kinase activitysearch glucokinase activitysearch protein bindingsearch ADP bindingsearch glucose bindingsearch magnesium ion bindingsearch transferase activitysearch protein phosphatase bindingsearch mannokinase activitysearch nucleotide bindingsearch fructokinase activitysearch catalytic activitysearch glucose transportsearch positive regulation of phosphorylationsearch glucose homeostasissearch response to glucosesearch carbohydrate phosphorylationsearch second-messenger-mediated signalingsearch cellular response to leptin stimulussearch hexose transportsearch regulation of glucose transportsearch phosphorylationsearch endocrine pancreas developmentsearch positive regulation of glycolytic processsearch positive regulation of insulin secretionsearch regulation of potassium ion transportsearch regulation of glycolytic processsearch transmembrane transportsearch regulation of insulin secretionsearch positive regulation of glycogen biosynthetic processsearch NADP metabolic processsearch glycogen biosynthetic processsearch glucose 6-phosphate metabolic processsearch negative regulation of epinephrine secretionsearch cellular response to glucose starvationsearch carbohydrate metabolic processsearch negative regulation of gluconeogenesissearch cellular glucose homeostasissearch glycolytic processsearch positive regulation of cytosolic calcium ion concentrationsearch fructose 2,6-bisphosphate metabolic processsearch cellular response to insulin stimulussearch detection of glucosesearch glucose metabolic processsearch small molecule metabolic processsearch calcium ion importsearch metabolic processsearch cytoplasmsearch nucleussearch secretory granulesearch cytosolsearch mitochondrionsearch nucleoplasmsearch cell cortexsearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch