3id8 Summary


Ternary complex of human pancreatic glucokinase crystallized with activator, glucose and AMP-PNP

The structure was published by Petit, P., Antoine, M., Ferry, G., et al., Gluais, L., Vincentelli, R., and Vuillard, L., in 2011 in a paper entitled "The active conformation of human glucokinase is not altered by allosteric activators" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glucokinase. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 470 residues which is 98% of the natural sequence. Out of 470 residues 450 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucokinase P35557 (12-465) (HXK4_HUMAN)search Homo sapienssearch 97% 470 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (12 - 465) Glucokinase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P35557) Hexokinase; domain 1search, Nucleotidyltransferase; domain 5search PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P35557) glycolytic processsearch transmembrane transportsearch NADP metabolic processsearch glycogen biosynthetic processsearch small molecule metabolic processsearch fructose 2,6-bisphosphate metabolic processsearch regulation of potassium ion transportsearch regulation of insulin secretionsearch response to glucosesearch carbohydrate metabolic processsearch endocrine pancreas developmentsearch hexose transportsearch regulation of glucose transportsearch cellular response to insulin stimulussearch second-messenger-mediated signalingsearch cellular response to leptin stimulussearch glucose transportsearch glucose metabolic processsearch glucose homeostasissearch positive regulation of glycolytic processsearch carbohydrate phosphorylationsearch negative regulation of gluconeogenesissearch positive regulation of glycogen biosynthetic processsearch positive regulation of cytosolic calcium ion concentrationsearch negative regulation of epinephrine secretionsearch regulation of glycolytic processsearch positive regulation of insulin secretionsearch detection of glucosesearch cellular response to glucose starvationsearch positive regulation of phosphorylationsearch phosphorylationsearch cellular glucose homeostasissearch glucose 6-phosphate metabolic processsearch metabolic processsearch calcium ion importsearch glucose bindingsearch kinase activitysearch catalytic activitysearch protein bindingsearch ATP bindingsearch fructokinase activitysearch phosphotransferase activity, alcohol group as acceptorsearch protein phosphatase bindingsearch glucokinase activitysearch hexokinase activitysearch nucleotide bindingsearch transferase activitysearch magnesium ion bindingsearch ADP bindingsearch mannokinase activitysearch cytosolsearch mitochondrionsearch nucleussearch cell cortexsearch nucleoplasmsearch cytoplasmsearch secretory granulesearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch