3ic0 Summary

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Crystal Structure of liganded hemoglobin in complex with a potent antisickling agent, INN-298

A publication describing this structure is not available. The depositing authors are Safo, M.Ksearch; Musayev, F.Nsearch; Gandhi, A.Ksearch; Jorge P.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin subunit alpha and Hemoglobin subunit beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin subunit alpha P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin subunit alpha P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin subunit beta P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin subunit beta P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin subunit alpha Homo sapiens
P68871 (2 - 147) Hemoglobin subunit beta Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) protein bindingsearch peroxidase activitysearch heme bindingsearch iron ion bindingsearch oxygen bindingsearch metal ion bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch extracellular regionsearch hemoglobin complexsearch cytosolic small ribosomal subunitsearch membranesearch cytosolsearch endocytic vesicle lumensearch blood microparticlesearch oxygen transportsearch hydrogen peroxide catabolic processsearch transportsearch bicarbonate transportsearch positive regulation of cell deathsearch small molecule metabolic processsearch response to hydrogen peroxidesearch oxidation-reduction processsearch protein heterooligomerizationsearch
B, D (P68871) oxygen bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch protein bindingsearch heme bindingsearch iron ion bindingsearch peroxidase activitysearch hemoglobin bindingsearch metal ion bindingsearch cytosolsearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch hemoglobin complexsearch extracellular regionsearch endocytic vesicle lumensearch blood microparticlesearch oxygen transportsearch bicarbonate transportsearch nitric oxide transportsearch positive regulation of nitric oxide biosynthetic processsearch platelet aggregationsearch regulation of blood vessel sizesearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch blood coagulationsearch renal absorptionsearch regulation of blood pressuresearch response to hydrogen peroxidesearch small molecule metabolic processsearch oxidation-reduction processsearch transportsearch positive regulation of cell deathsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch