3ic0 Summary

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Crystal Structure of liganded hemoglobin in complex with a potent antisickling agent, INN-298

A publication describing this structure is not available. The depositing authors are Safo, M.Ksearch; Musayev, F.Nsearch; Gandhi, A.Ksearch; Jorge P.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin subunit alpha and Hemoglobin subunit beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin subunit alpha P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin subunit alpha P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin subunit beta P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin subunit beta P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin subunit alpha Homo sapiens
P68871 (2 - 147) Hemoglobin subunit beta Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) heme bindingsearch oxygen bindingsearch protein bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch iron ion bindingsearch metal ion bindingsearch peroxidase activitysearch bicarbonate transportsearch small molecule metabolic processsearch transportsearch positive regulation of cell deathsearch oxidation-reduction processsearch response to hydrogen peroxidesearch oxygen transportsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch extracellular regionsearch hemoglobin complexsearch membranesearch endocytic vesicle lumensearch cytosolic small ribosomal subunitsearch cytosolsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch
B, D (P68871) heme bindingsearch oxygen bindingsearch iron ion bindingsearch protein bindingsearch oxygen transporter activitysearch hemoglobin bindingsearch peroxidase activitysearch metal ion bindingsearch haptoglobin bindingsearch hydrogen peroxide catabolic processsearch oxygen transportsearch protein heterooligomerizationsearch regulation of blood vessel sizesearch oxidation-reduction processsearch platelet aggregationsearch renal absorptionsearch small molecule metabolic processsearch blood coagulationsearch regulation of blood pressuresearch transportsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch nitric oxide transportsearch positive regulation of nitric oxide biosynthetic processsearch bicarbonate transportsearch extracellular regionsearch hemoglobin complexsearch endocytic vesicle lumensearch extracellular vesicular exosomesearch blood microparticlesearch cytosolsearch haptoglobin-hemoglobin complexsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch