Crystal Structure of a Pyrazolopyrimidine Inhibitor Bound to PI3 Kinase Gamma
The structure was published by Zask, A., Verheijen, J.C., Curran, K., et al., Ayral-Kaloustian, S., Mansour, T.S., and Yu, K., in 2009 in a paper entitled "ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin: Design and Synthesis of Highly Potent and Selective Pyrazolopyrimidines." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.798 Å and deposited in 2009.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform. This molecule has the UniProt identifier P48736 (PK3CG_HUMAN). The sample contained 966 residues which is < 90% of the natural sequence. Out of 966 residues 808 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: