Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with BMS-754807 [1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoro-3-pyridinyl)-2-methyl-L-prolinamide]
The structure was published by Wittman, M.D., Carboni, J.M., Yang, Z., et al., Zhang, G., Zimmermann, K., and Vyas, D.M., in 2009 in a paper entitled "Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.08 Å and deposited in 2009.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Insulin-like growth factor 1 receptor. This molecule has the UniProt identifier P08069 (IGF1R_HUMAN). The sample contained 315 residues which is < 90% of the natural sequence. Out of 315 residues 289 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: