3i81 Summary


Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with BMS-754807 [1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoro-3-pyridinyl)-2-methyl-L-prolinamide]

The structure was published by Wittman, M.D., Carboni, J.M., Yang, Z., et al., Zhang, G., Zimmermann, K., and Vyas, D.M., in 2009 in a paper entitled "Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.08 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Insulin-like growth factor 1 receptor. This molecule has the UniProt identifier P08069 (IGF1R_HUMAN)search. The sample contained 315 residues which is < 90% of the natural sequence. Out of 315 residues 289 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Insulin-like growth factor 1 receptor P08069 (982-1286) (IGF1R_HUMAN)search Homo sapienssearch < 90% 315 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P08069 (982 - 1286) Insulin-like growth factor 1 receptor Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P08069) protein phosphorylationsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch ATP bindingsearch protein kinase activitysearch transmembrane receptor protein tyrosine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein tyrosine kinase activitysearch membranesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class II, conserved sitesearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch