3i6w Summary

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Structure and Activation Mechanism of the CHK2 DNA-Damage Checkpoint Kinase

The structure was published by Cai, Z., Chehab, N.H., and Pavletich, N.P., in 2009 in a paper entitled "Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.25 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Serine/threonine-protein kinase Chk2.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Serine/threonine-protein kinase Chk2 O96017 (70-512) (CHK2_HUMAN)search Homo sapienssearch < 90% 443 86%
B Serine/threonine-protein kinase Chk2 O96017 (70-512) (CHK2_HUMAN)search Homo sapienssearch < 90% 443 86%
C Serine/threonine-protein kinase Chk2 O96017 (70-512) (CHK2_HUMAN)search Homo sapienssearch < 90% 443 86%
D Serine/threonine-protein kinase Chk2 O96017 (70-512) (CHK2_HUMAN)search Homo sapienssearch < 90% 443 86%
E Serine/threonine-protein kinase Chk2 O96017 (70-512) (CHK2_HUMAN)search Homo sapienssearch < 90% 443 86%
F Serine/threonine-protein kinase Chk2 O96017 (70-512) (CHK2_HUMAN)search Homo sapienssearch < 90% 443 86%
G Serine/threonine-protein kinase Chk2 O96017 (70-512) (CHK2_HUMAN)search Homo sapienssearch < 90% 443 86%
H Serine/threonine-protein kinase Chk2 O96017 (70-512) (CHK2_HUMAN)search Homo sapienssearch < 90% 443 86%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O96017 (70 - 512) Serine/threonine-protein kinase Chk2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F, G, H Tumour Suppressor Smad4search, Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch, FHA domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B, C, D, E, F, G, H (O96017) ATP bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A, B, C, D, E, F, G, H Forkhead-associated (FHA) domainsearch Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch SMAD/FHA domainsearch Protein kinase-like domainsearch