3i5s Summary

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Crystal structure of PI3K SH3

The structure was published by Batra-Safferling, R., Granzin, J., Modder, S., Hoffmann, S., and Willbold, D., in 2010 in a paper entitled "Structural studies of the phosphatidylinositol 3-kinase (PI3K) SH3 domain in complex with a peptide ligand: role of the anchor residue in ligand binding." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Phosphatidylinositol 3-kinase regulatory subunit alpha.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Phosphatidylinositol 3-kinase regulatory subunit alpha P27986 (1-83) (P85A_HUMAN)search Homo sapienssearch < 90% 83 92%
B Phosphatidylinositol 3-kinase regulatory subunit alpha P27986 (1-83) (P85A_HUMAN)search Homo sapienssearch < 90% 83 92%
C Phosphatidylinositol 3-kinase regulatory subunit alpha P27986 (1-83) (P85A_HUMAN)search Homo sapienssearch < 90% 83 92%
D Phosphatidylinositol 3-kinase regulatory subunit alpha P27986 (1-83) (P85A_HUMAN)search Homo sapienssearch < 90% 83 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P27986 (1 - 83) Phosphatidylinositol 3-kinase regulatory subunit alpha Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D SH3 Domainssearch Variant SH3 domainsearch

Chain ID Cellular component (GO) Molecular function (GO)
A, B, C, D (P27986) phosphatidylinositol 3-kinase complexsearch phosphatidylinositol 3-kinase regulator activitysearch

Chain InterPro annotation
A, B, C, D Src homology-3 domainsearch PI3 kinase, P85 regulatory subunitsearch Variant SH3 domainsearch