3i5i Summary

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PDB entry 3i5i (supersedes 2ekw)

The crystal structure of squid myosin S1 in the presence of SO4 2-

The structure was published by Yang, Y., Gourinath, S., Kovacs, M., et al., Szent-Gyorgyi, A.G., Brown, J.H., and Cohen, C., in 2007 in a paper entitled "Rigor-like structures from muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.3 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Myosin heavy chain isoform A, Myosin regulatory light chain LC-2, mantle muscle, and Myosin catalytic light chain LC-1, mantle muscle.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Myosin heavy chain isoform A O44934 (1-839) (O44934_DORPE)search Doryteuthis pealeiisearch < 90% 839 96%
B Myosin regulatory light chain LC-2, mantle muscle P08052 (1-153) (MLR_TODPA)search Todarodes pacificussearch 100% 153 94%
C Myosin catalytic light chain LC-1, mantle muscle P05945 (2-160) (MLE_TODPA)search Todarodes pacificussearch 99% 159 98%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
O44934 (1 - 839) Myosin heavy chain isoform A Doryteuthis pealeii
P08052 (1 - 153) Myosin regulatory light chain LC-2, mantle muscle Todarodes pacificus
P05945 (2 - 160) Myosin catalytic light chain LC-1, mantle muscle Todarodes pacificus

Chain Structural classification (CATH) Sequence family (Pfam)
A Myosin head (motor domain)search, IQ calmodulin-binding motifsearch, Myosin N-terminal SH3-like domainsearch
B (P08052) EF-handsearch PF00036: EF handsearch
C (P05945) EF-handsearch

Chain ID Cellular component (GO) Molecular function (GO)
A (O44934) myosin complexsearch ATP bindingsearch motor activitysearch
B (P08052) myosin complexsearch metal ion bindingsearch calcium ion bindingsearch
C (P05945) myosin complexsearch calcium ion bindingsearch

Chain InterPro annotation
A IQ motif, EF-hand binding sitesearch Myosin head, motor domainsearch Myosin, N-terminal, SH3-likesearch Myosin-like IQ motif-containing domainsearch P-loop containing nucleoside triphosphate hydrolasesearch
B EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch
C EF-hand domainsearch EF-hand domain pairsearch