3i4b Summary

pdbe.org/3i4b
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Crystal structure of GSK3b in complex with a pyrimidylpyrrole inhibitor

The structure was published by Aronov, A.M., Tang, Q., Martinez-Botella, G., et al., Straub, J., ter Haar, E., and Xie, X., in 2009 in a paper entitled "Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glycogen synthase kinase-3 beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glycogen synthase kinase-3 beta P49841 (7-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 414 86%
B Glycogen synthase kinase-3 beta P49841 (7-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 414 86%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (7 - 420) Glycogen synthase kinase-3 beta Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P49841) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P49841) protein phosphorylationsearch intracellular signal transductionsearch negative regulation of apoptotic processsearch positive regulation of cell-matrix adhesionsearch positive regulation of peptidyl-serine phosphorylationsearch negative regulation of cardiac muscle hypertrophysearch positive regulation of apoptotic processsearch positive regulation of protein bindingsearch positive regulation of stem cell differentiationsearch carbohydrate metabolic processsearch epidermal growth factor receptor signaling pathwaysearch phosphorylationsearch axonogenesissearch glycogen metabolic processsearch canonical Wnt signaling pathwaysearch cellular response to mechanical stimulussearch regulation of microtubule-based processsearch negative regulation of protein complex assemblysearch ER overload responsesearch nervous system developmentsearch response to drugsearch negative regulation of signal transductionsearch regulation of neuronal synaptic plasticitysearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch response to lithium ionsearch fibroblast growth factor receptor signaling pathwaysearch circadian rhythmsearch negative regulation of MAP kinase activitysearch myoblast fusionsearch organ morphogenesissearch epithelial to mesenchymal transitionsearch hippocampus developmentsearch establishment of cell polaritysearch cellular response to interleukin-3search peptidyl-serine phosphorylationsearch protein export from nucleussearch Wnt signaling pathwaysearch rhythmic processsearch negative regulation of glycogen biosynthetic processsearch positive regulation of protein catabolic processsearch innate immune responsesearch superior temporal gyrus developmentsearch cell differentiationsearch Fc-epsilon receptor signaling pathwaysearch myotube differentiationsearch multicellular organismal developmentsearch positive regulation of protein export from nucleussearch neurotrophin TRK receptor signaling pathwaysearch establishment or maintenance of cell polaritysearch negative regulation of type B pancreatic cell developmentsearch positive regulation of Rac GTPase activitysearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch axon guidancesearch negative regulation of NFAT protein import into nucleussearch phosphatidylinositol-mediated signalingsearch hypermethylation of CpG islandsearch protein localization to microtubulesearch negative regulation of glycogen (starch) synthase activitysearch negative regulation of dendrite morphogenesissearch cell migrationsearch positive regulation of protein complex assemblysearch re-entry into mitotic cell cyclesearch regulation of gene expression by genetic imprintingsearch negative regulation of protein bindingsearch fat cell differentiationsearch extrinsic apoptotic signaling pathway in absence of ligandsearch positive regulation of peptidyl-threonine phosphorylationsearch negative regulation of canonical Wnt signaling pathwaysearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein bindingsearch tau-protein kinase activitysearch beta-catenin bindingsearch protein serine/threonine kinase activitysearch ATP bindingsearch ubiquitin protein ligase bindingsearch transferase activitysearch kinase activitysearch nucleotide bindingsearch ionotropic glutamate receptor bindingsearch p53 bindingsearch protein kinase bindingsearch integrin bindingsearch protein kinase A catalytic subunit bindingsearch tau protein bindingsearch NF-kappaB bindingsearch RNA polymerase II transcription factor bindingsearch nucleussearch cytosolsearch cytoplasmsearch protein complexsearch centrosomesearch membranesearch growth conesearch beta-catenin destruction complexsearch ribonucleoprotein complexsearch dendritic shaftsearch perinuclear region of cytoplasmsearch plasma membranesearch membrane raftsearch neuronal cell bodysearch dendritic spinesearch membrane-bounded organellesearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch