3hv7 Summary


Human p38 MAP Kinase in Complex with RL38

The structure was published by Kluter, S., Grutter, C., Naqvi, T., et al., Pawar, V., Getlik, M., and Rauh, D., in 2010 in a paper entitled "Displacement assay for the detection of stabilizers of inactive kinase conformations." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 329 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) ATP bindingsearch MAP kinase activitysearch protein kinase activitysearch kinase activitysearch protein bindingsearch NFAT protein bindingsearch protein serine/threonine kinase activitysearch MAP kinase kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch transferase activitysearch nucleotide bindingsearch protein phosphorylationsearch RNA metabolic processsearch regulation of transcription from RNA polymerase II promotersearch chondrocyte differentiationsearch stress-activated MAPK cascadesearch p38MAPK cascadesearch chemotaxissearch TRIF-dependent toll-like receptor signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch toll-like receptor signaling pathwaysearch positive regulation of myotube differentiationsearch toll-like receptor 2 signaling pathwaysearch toll-like receptor 4 signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch muscle cell differentiationsearch signal transduction in response to DNA damagesearch signal transductionsearch DNA damage checkpointsearch regulation of transcription, DNA-templatedsearch cellular component movementsearch platelet activationsearch response to muramyl dipeptidesearch positive regulation of erythrocyte differentiationsearch osteoclast differentiationsearch MyD88-dependent toll-like receptor signaling pathwaysearch intracellular signal transductionsearch Ras protein signal transductionsearch positive regulation of myoblast fusionsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch striated muscle cell differentiationsearch cell surface receptor signaling pathwaysearch lipopolysaccharide-mediated signaling pathwaysearch skeletal muscle tissue developmentsearch peptidyl-serine phosphorylationsearch positive regulation of myoblast differentiationsearch transcription, DNA-templatedsearch blood coagulationsearch toll-like receptor 3 signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch MyD88-independent toll-like receptor signaling pathwaysearch negative regulation of canonical Wnt signaling pathwaysearch cellular response to ionizing radiationsearch stress-induced premature senescencesearch 3'-UTR-mediated mRNA stabilizationsearch positive regulation of reactive oxygen species metabolic processsearch positive regulation of muscle cell differentiationsearch cell morphogenesissearch cellular response to vascular endothelial growth factor stimulussearch innate immune responsesearch apoptotic processsearch toll-like receptor 9 signaling pathwaysearch vascular endothelial growth factor receptor signaling pathwaysearch cellular response to DNA damage stimulussearch gene expressionsearch cellular response to lipopolysaccharidesearch phosphorylationsearch positive regulation of protein import into nucleussearch neurotrophin TRK receptor signaling pathwaysearch glucose metabolic processsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch toll-like receptor 5 signaling pathwaysearch response to lipopolysaccharidesearch cartilage condensationsearch response to stresssearch mRNA metabolic processsearch positive regulation of blood vessel endothelial cell migrationsearch activation of MAPK activitysearch angiogenesissearch myoblast differentiation involved in skeletal muscle regenerationsearch fatty acid oxidationsearch extracellular vesicular exosomesearch cytosolsearch nucleoplasmsearch cellsearch spindle polesearch nucleussearch cytoplasmsearch mitochondrionsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch