3hv6 Summary


Human p38 MAP Kinase in Complex with RL39

The structure was published by Kluter, S., Grutter, C., Naqvi, T., et al., Pawar, V., Getlik, M., and Rauh, D., in 2010 in a paper entitled "Displacement assay for the detection of stabilizers of inactive kinase conformations." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 329 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) protein kinase activitysearch kinase activitysearch protein bindingsearch MAP kinase activitysearch NFAT protein bindingsearch protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch MAP kinase kinase activitysearch nucleotide bindingsearch transferase activitysearch neurotrophin TRK receptor signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch negative regulation of canonical Wnt signaling pathwaysearch p38MAPK cascadesearch stress-induced premature senescencesearch MyD88-independent toll-like receptor signaling pathwaysearch toll-like receptor 4 signaling pathwaysearch angiogenesissearch positive regulation of myoblast fusionsearch intracellular signal transductionsearch response to muramyl dipeptidesearch cellular response to vascular endothelial growth factor stimulussearch protein phosphorylationsearch stress-activated MAPK cascadesearch regulation of transcription from RNA polymerase II promotersearch positive regulation of myotube differentiationsearch MyD88-dependent toll-like receptor signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch transcription, DNA-templatedsearch activation of MAPK activitysearch blood coagulationsearch peptidyl-serine phosphorylationsearch positive regulation of reactive oxygen species metabolic processsearch toll-like receptor 9 signaling pathwaysearch response to lipopolysaccharidesearch fatty acid oxidationsearch cellular response to ionizing radiationsearch cell morphogenesissearch positive regulation of erythrocyte differentiationsearch myoblast differentiation involved in skeletal muscle regenerationsearch positive regulation of muscle cell differentiationsearch chondrocyte differentiationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch osteoclast differentiationsearch toll-like receptor 10 signaling pathwaysearch signal transduction in response to DNA damagesearch 3'-UTR-mediated mRNA stabilizationsearch lipopolysaccharide-mediated signaling pathwaysearch cellular response to DNA damage stimulussearch positive regulation of myoblast differentiationsearch regulation of transcription, DNA-templatedsearch regulation of sequence-specific DNA binding transcription factor activitysearch positive regulation of protein import into nucleussearch glucose metabolic processsearch innate immune responsesearch phosphorylationsearch toll-like receptor signaling pathwaysearch DNA damage checkpointsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch chemotaxissearch gene expressionsearch skeletal muscle tissue developmentsearch cellular response to lipopolysaccharidesearch Ras protein signal transductionsearch muscle cell differentiationsearch striated muscle cell differentiationsearch response to stresssearch cell surface receptor signaling pathwaysearch toll-like receptor 5 signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch platelet activationsearch cartilage condensationsearch mRNA metabolic processsearch signal transductionsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch apoptotic processsearch cellular component movementsearch RNA metabolic processsearch vascular endothelial growth factor receptor signaling pathwaysearch toll-like receptor 3 signaling pathwaysearch positive regulation of blood vessel endothelial cell migrationsearch nucleoplasmsearch cytosolsearch nucleussearch cytoplasmsearch extracellular vesicular exosomesearch cellsearch mitochondrionsearch spindle polesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch