3hv5 Summary


Human p38 MAP Kinase in Complex with RL24

The structure was published by Kluter, S., Grutter, C., Naqvi, T., et al., Pawar, V., Getlik, M., and Rauh, D., in 2010 in a paper entitled "Displacement assay for the detection of stabilizers of inactive kinase conformations." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.25 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Mitogen-activated protein kinase 14.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 94%
B Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (Q16539) protein kinase activitysearch protein bindingsearch NFAT protein bindingsearch protein serine/threonine kinase activitysearch MAP kinase activitysearch ATP bindingsearch transferase activitysearch nucleotide bindingsearch kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch MAP kinase kinase activitysearch blood coagulationsearch peptidyl-serine phosphorylationsearch toll-like receptor signaling pathwaysearch MyD88-dependent toll-like receptor signaling pathwaysearch Ras protein signal transductionsearch positive regulation of muscle cell differentiationsearch positive regulation of myotube differentiationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch muscle cell differentiationsearch platelet activationsearch response to lipopolysaccharidesearch toll-like receptor 10 signaling pathwaysearch neurotrophin TRK receptor signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch cellular response to lipopolysaccharidesearch cellular response to ionizing radiationsearch signal transductionsearch toll-like receptor 4 signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch lipopolysaccharide-mediated signaling pathwaysearch apoptotic processsearch p38MAPK cascadesearch activation of MAPK activitysearch toll-like receptor 5 signaling pathwaysearch vascular endothelial growth factor receptor signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch positive regulation of myoblast fusionsearch chondrocyte differentiationsearch regulation of transcription, DNA-templatedsearch positive regulation of myoblast differentiationsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch cartilage condensationsearch negative regulation of canonical Wnt signaling pathwaysearch transcription, DNA-templatedsearch toll-like receptor 2 signaling pathwaysearch osteoclast differentiationsearch protein phosphorylationsearch positive regulation of reactive oxygen species metabolic processsearch positive regulation of protein import into nucleussearch striated muscle cell differentiationsearch RNA metabolic processsearch fatty acid oxidationsearch signal transduction in response to DNA damagesearch mRNA metabolic processsearch toll-like receptor 3 signaling pathwaysearch positive regulation of blood vessel endothelial cell migrationsearch chemotaxissearch 3'-UTR-mediated mRNA stabilizationsearch cellular response to DNA damage stimulussearch phosphorylationsearch TRIF-dependent toll-like receptor signaling pathwaysearch innate immune responsesearch gene expressionsearch cellular component movementsearch DNA damage checkpointsearch cell morphogenesissearch myoblast differentiation involved in skeletal muscle regenerationsearch regulation of transcription from RNA polymerase II promotersearch glucose metabolic processsearch response to muramyl dipeptidesearch angiogenesissearch regulation of sequence-specific DNA binding transcription factor activitysearch stress-activated MAPK cascadesearch skeletal muscle tissue developmentsearch intracellular signal transductionsearch stress-induced premature senescencesearch cell surface receptor signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of erythrocyte differentiationsearch cellular response to vascular endothelial growth factor stimulussearch cytoplasmsearch cellsearch cytosolsearch mitochondrionsearch nucleoplasmsearch nucleussearch spindle polesearch extracellular vesicular exosomesearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch