3hs6 Summary

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X-ray crystal structure of eicosapentaenoic acid bound to the cyclooxygenase channel of cyclooxygenase-2

The structure was published by Vecchio, A.J., Simmons, D.M., and Malkowski, M.G., in 2010 in a paper entitled "Structural basis of fatty acid substrate binding to cyclooxygenase-2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Prostaglandin G/H synthase 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Prostaglandin G/H synthase 2 Q05769 (20-604) (PGH2_MOUSE)search Mus musculussearch 94% 591 93%
B Prostaglandin G/H synthase 2 Q05769 (20-604) (PGH2_MOUSE)search Mus musculussearch 94% 591 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q05769 (20 - 604) Prostaglandin G/H synthase 2 Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (Q05769) Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (Q05769) maintenance of blood-brain barriersearch ovulationsearch sensory perception of painsearch positive regulation of apoptotic processsearch response to glucocorticoidsearch positive regulation of smooth muscle contractionsearch prostaglandin biosynthetic processsearch cellular response to UVsearch regulation of cell proliferationsearch cyclooxygenase pathwaysearch response to lithium ionsearch positive regulation of smooth muscle cell proliferationsearch response to estradiolsearch response to radiationsearch memorysearch oxidation-reduction processsearch regulation of blood pressuresearch inflammatory responsesearch positive regulation of platelet-derived growth factor productionsearch positive regulation of transforming growth factor beta productionsearch positive regulation of synaptic transmission, glutamatergicsearch response to organic cyclic compoundsearch angiogenesissearch negative regulation of smooth muscle contractionsearch bone mineralizationsearch response to lipopolysaccharidesearch cellular response to hypoxiasearch brown fat cell differentiationsearch response to organonitrogen compoundsearch fatty acid metabolic processsearch cellular response to mechanical stimulussearch positive regulation vascular endothelial growth factor productionsearch response to manganese ionsearch positive regulation of vasoconstrictionsearch learningsearch response to drugsearch keratinocyte differentiationsearch positive regulation of fever generationsearch negative regulation of cell proliferationsearch response to tumor necrosis factorsearch positive regulation of synaptic plasticitysearch negative regulation of cell cyclesearch response to organic substancesearch positive regulation of fibroblast growth factor productionsearch negative regulation of calcium ion transportsearch hair cyclesearch fatty acid biosynthetic processsearch response to oxidative stresssearch positive regulation of cell deathsearch embryo implantationsearch response to fatty acidsearch positive regulation of nitric oxide biosynthetic processsearch cellular response to ATPsearch positive regulation of NF-kappaB import into nucleussearch prostaglandin metabolic processsearch anagensearch lipid metabolic processsearch response to vitamin Dsearch decidualizationsearch response to fructosesearch negative regulation of synaptic transmission, dopaminergicsearch positive regulation of brown fat cell differentiationsearch positive regulation of cell migration involved in sprouting angiogenesissearch response to cytokinesearch dioxygenase activitysearch oxidoreductase activitysearch heme bindingsearch prostaglandin-endoperoxide synthase activitysearch peroxidase activitysearch protein homodimerization activitysearch lipid bindingsearch metal ion bindingsearch enzyme bindingsearch oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygensearch endoplasmic reticulumsearch cytoplasmsearch neuron projectionsearch membranesearch organelle membranesearch intracellular membrane-bounded organellesearch endoplasmic reticulum membranesearch protein complexsearch

Chain InterPro annotation
A, B Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 2search