Crystal Structure of Human p38alpha complexed with a pyrimidopyridazinone compound
The structure was published by Selness, S.R., Devraj, R.V., Monahan, J.B., et al., Alvira, E., Naing, W., and Blevis-Bal, R., in 2009 in a paper entitled "Discovery of N-substituted pyridinones as potent and selective inhibitors of p38 kinase." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2009.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN). The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 329 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: