3hp5 Summary


Crystal Structure of Human p38alpha complexed with a pyrimidopyridazinone compound

The structure was published by Selness, S.R., Devraj, R.V., Monahan, J.B., et al., Alvira, E., Naing, W., and Blevis-Bal, R., in 2009 in a paper entitled "Discovery of N-substituted pyridinones as potent and selective inhibitors of p38 kinase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 329 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch MAP kinase activitysearch protein kinase activitysearch protein bindingsearch MAP kinase kinase activitysearch nucleotide bindingsearch protein serine/threonine kinase activitysearch kinase activitysearch NFAT protein bindingsearch transferase activitysearch protein phosphorylationsearch lipopolysaccharide-mediated signaling pathwaysearch striated muscle cell differentiationsearch regulation of transcription from RNA polymerase II promotersearch 3'-UTR-mediated mRNA stabilizationsearch intracellular signal transductionsearch response to stresssearch positive regulation of myoblast fusionsearch positive regulation of muscle cell differentiationsearch positive regulation of erythrocyte differentiationsearch apoptotic processsearch regulation of transcription, DNA-templatedsearch positive regulation of myoblast differentiationsearch osteoclast differentiationsearch chemotaxissearch stress-induced premature senescencesearch toll-like receptor 9 signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch angiogenesissearch peptidyl-serine phosphorylationsearch negative regulation of canonical Wnt signaling pathwaysearch positive regulation of blood vessel endothelial cell migrationsearch signal transduction in response to DNA damagesearch signal transductionsearch toll-like receptor signaling pathwaysearch cell morphogenesissearch fatty acid oxidationsearch gene expressionsearch toll-like receptor 5 signaling pathwaysearch stress-activated MAPK cascadesearch Ras protein signal transductionsearch MyD88-independent toll-like receptor signaling pathwaysearch blood coagulationsearch mRNA metabolic processsearch positive regulation of protein import into nucleussearch cellular component movementsearch toll-like receptor 10 signaling pathwaysearch MyD88-dependent toll-like receptor signaling pathwaysearch phosphorylationsearch toll-like receptor 3 signaling pathwaysearch MAPK cascadesearch chondrocyte differentiationsearch positive regulation of transcription from RNA polymerase II promotersearch vascular endothelial growth factor receptor signaling pathwaysearch glucose metabolic processsearch innate immune responsesearch cartilage condensationsearch muscle cell differentiationsearch neurotrophin TRK receptor signaling pathwaysearch response to lipopolysaccharidesearch toll-like receptor 4 signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch activation of MAPK activitysearch RNA metabolic processsearch cellular response to ionizing radiationsearch cellular response to lipopolysaccharidesearch regulation of sequence-specific DNA binding transcription factor activitysearch transcription, DNA-templatedsearch cellular response to vascular endothelial growth factor stimulussearch p38MAPK cascadesearch response to muramyl dipeptidesearch TRIF-dependent toll-like receptor signaling pathwaysearch positive regulation of myotube differentiationsearch skeletal muscle tissue developmentsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch cellular response to DNA damage stimulussearch positive regulation of reactive oxygen species metabolic processsearch platelet activationsearch DNA damage checkpointsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch cell surface receptor signaling pathwaysearch nucleussearch nucleoplasmsearch cytoplasmsearch cytosolsearch cellsearch mitochondrionsearch extracellular vesicular exosomesearch spindle polesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch