› 3hn8

X-ray diffraction
3.5Å resolution

Crystal structure of synaptotagmin

Released:
DOI: 10.2210/pdb3hn8/pdb
PDB entry 3hn8 coloured by chain, front view.
PDB entry 3hn8 coloured by chain, side view.
PDB entry 3hn8 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Molecular mechanism of the synaptotagmin-SNARE interaction in Ca2+-triggered vesicle fusion.
Vrljic M, Strop P, Ernst JA, Sutton RB, Chu S, Brunger AT
Nat Struct Mol Biol 17 325-31 (2010)
PMID: 20173762

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154178 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Synaptotagmin-3 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 296 amino acids
Theoretical weight: 33.18 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P40748 (Residues: 292-587; Coverage: 50%)
Gene name: Syt3
Sequence domains: C2 domain
Structure domains: C2 domain

Ligands and Environments

2 bound ligands:
Ligand CA 18 x CA
Ligand ZN 3 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P41212
Unit cell:
a: 205.675Å b: 205.675Å c: 143.125Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.24 0.238 0.259
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Molecular machines governing exocytosis of synaptic vesicles.
Jahn et al. (2012)
6 more

4 mentions without citation

Molecular mechanism of the synaptotagmin-SNARE interaction in Ca2+-triggered vesicle fusion.
Vrljic et al. (2010)
3 more