3hmy Summary

pdbe.org/3hmy
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Crystal structure of HCR/T complexed with GT2

The structure was published by Chen, C., Fu, Z., Kim, J.J., Barbieri, J.T., and Baldwin, M.R., in 2009 in a paper entitled "Gangliosides as high affinity receptors for tetanus neurotoxin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Tetanus toxin. This molecule has the UniProt identifier P04958 (TETX_CLOTE)search. The sample contained 450 residues which is < 90% of the natural sequence. Out of 450 residues 442 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tetanus toxin P04958 (866-1315) (TETX_CLOTE)search Clostridium tetani E88search < 90% 450 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04958 (866 - 1315) Tetanus toxin Clostridium tetani

Chain Structural classification (CATH) Sequence family (Pfam)
A Jelly Rollssearch, Trefoil (Acidic Fibroblast Growth Factor, subunit A)search Clostridium neurotoxin, C-terminal receptor bindingsearch, Clostridium neurotoxin, Translocation domainsearch, Clostridium neurotoxin, N-terminal receptor bindingsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P04958) inhibition of neurotransmitter uptakesearch pathogenesissearch extracellular regionsearch toxin receptor bindingsearch metalloendopeptidase activitysearch

Chain InterPro annotation
A search Kunitz inhibitor ST1-likesearch Clostridium neurotoxin, receptor binding N-terminalsearch Clostridium neurotoxin, receptor-binding C-terminalsearch Concanavalin A-like lectin/glucanase domainsearch