GO terms
Biochemical function:
Biological process:
- negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
- negative regulation of vascular endothelial growth factor signaling pathway
- positive regulation of NK T cell activation
- negative regulation of protein secretion
- positive regulation of lymphocyte proliferation
- negative regulation of smooth muscle cell proliferation
- positive regulation of cell adhesion
- positive regulation of tyrosine phosphorylation of STAT protein
- interleukin-12-mediated signaling pathway
- positive regulation of smooth muscle cell apoptotic process
- positive regulation of mononuclear cell proliferation
- positive regulation of natural killer cell activation
- positive regulation of type II interferon production
- negative regulation of interleukin-17 production
- cell migration
- response to UV-B
- positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
- positive regulation of T cell mediated cytotoxicity
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
IPR003006
Domain description:
Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
Occurring in:
IPR003530
Domain description:
Long hematopoietin receptor, soluble alpha chain, conserved site
Occurring in:
Occurring in:
CATH domains
![The deposited structure of PDB entry 3hmx contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in USTEKINUMAB FAB LIGHT CHAIN. Showing 2 copies in chain C [auth L].](https://www.ebi.ac.uk/pdbe/static/entry/3hmx_3_L_CATH_2.60.40.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>3hmx</span> contains 2 copies of CATH domain <span class='highlight'>2.60.40.10 (Immunoglobulin-like)</span> in <span class='highlight'>USTEKINUMAB FAB LIGHT CHAIN</span>. Showing 2 copies in chain <span class='highlight'>C [auth L]</span>.")
![The deposited structure of PDB entry 3hmx contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in USTEKINUMAB FAB HEAVY CHAIN. Showing 2 copies in chain D [auth H].](https://www.ebi.ac.uk/pdbe/static/entry/3hmx_4_H_CATH_2.60.40.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>3hmx</span> contains 2 copies of CATH domain <span class='highlight'>2.60.40.10 (Immunoglobulin-like)</span> in <span class='highlight'>USTEKINUMAB FAB HEAVY CHAIN</span>. Showing 2 copies in chain <span class='highlight'>D [auth H]</span>.")
