3hmm Summary


PDB entry 3hmm (supersedes 3gxj)

Structure of Alk5 + GW855857

The structure was published by Gellibert, F., Fouchet, M.-H., Nguyen, V.-L., et al., de Gouville, A.-C., Huet, S., and Dodic, N., in 2009 in a paper entitled "Design of novel quinazoline derivatives and related analogues as potent and selective ALK5 inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of TGF-beta receptor type-1. This molecule has the UniProt identifier P36897 (TGFR1_HUMAN)search. The sample contained 303 residues which is < 90% of the natural sequence. Out of 303 residues 293 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TGF-beta receptor type-1 P36897 (201-503) (TGFR1_HUMAN)search Homo sapienssearch < 90% 303 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P36897 (201 - 503) TGF-beta receptor type-1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch, Transforming growth factor beta type I GS-motifsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P36897) receptor signaling protein serine/threonine kinase activitysearch protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch membranesearch protein phosphorylationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch

Chain InterPro annotation
A Ser/Thr protein kinase, TGFB receptorsearch Protein kinase domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch