PDB entry 3hmm (supersedes 3gxj)
Structure of Alk5 + GW855857
The structure was published by Gellibert, F., Fouchet, M.-H., Nguyen, V.-L., et al., de Gouville, A.-C., Huet, S., and Dodic, N., in 2009 in a paper entitled "Design of novel quinazoline derivatives and related analogues as potent and selective ALK5 inhibitors" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2009.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of TGF-beta receptor type-1. This molecule has the UniProt identifier P36897 (TGFR1_HUMAN). The sample contained 303 residues which is < 90% of the natural sequence. Out of 303 residues 293 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: