3hmi Summary

pdbe.org/3hmi
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The crystal structure of human ABL2 in complex with 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE

A publication describing this structure is not available. The depositing authors are Ugochukwu, E.search; Salah, E.search; Barr, A.search; Mahajan, P.search; Shrestha, B.search; Savitsky, P.search; Chaikuad, A.search; Allerston, C.search; von Delft, F.search; Bountra, C.search; Arrowsmith, C.H.search; Weigelt, J.search; Edwards, A.search; Knapp, S.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.65 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Tyrosine-protein kinase ABL2. This molecule has the UniProt identifier P42684 (ABL2_HUMAN)search. The sample contained 292 residues which is < 90% of the natural sequence. Out of 292 residues 263 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tyrosine-protein kinase ABL2 P42684 (279-546) (ABL2_HUMAN)search Homo sapienssearch < 90% 292 91%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P42684 (279 - 546) Tyrosine-protein kinase ABL2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P42684) ATP bindingsearch protein kinase activitysearch protein tyrosine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch