3hlv Summary


Crystal structure of human Estrogen Receptor Alpha Ligand-Binding Domain in complex with a Glucocorticoid Receptor Interacting Protein 1 Nr Box II Peptide and 16-alpha-hydroxy-estrone ((8S,9R,13S,14R,16R)-3,16-dihydroxy-13-methyl-7,8,9,11,12,14,15, 16-octahydro-6H-cyclopenta[a]phenanthren-17-one

A publication describing this structure is not available. The depositing authors are Rajan, S.S.search; Kim, Y.search; Vanek, K.search; Joachimiak, A.search; Greene, G.L.search

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Estrogen receptor and Nuclear receptor coactivator 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Estrogen receptor P03372 (298-550) (ESR1_HUMAN)search Homo sapienssearch < 90% 253 94%
B Estrogen receptor P03372 (298-550) (ESR1_HUMAN)search Homo sapienssearch < 90% 253 94%
C Nuclear receptor coactivator 2 Q9WUI9 (686-698) (NCOA2_RAT)search Rattus norvegicussearch < 90% 13 76%
D Nuclear receptor coactivator 2 Q9WUI9 (686-698) (NCOA2_RAT)search Rattus norvegicussearch < 90% 13 76%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P03372 (298 - 550) Estrogen receptor Homo sapiens
Q9WUI9 (686 - 698) Nuclear receptor coactivator 2

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
C, D Steroid receptor coactivatorsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P03372) regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch steroid hormone receptor activitysearch DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch nucleussearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
C, D Nuclear receptor coactivator Src-1search