3hll Summary


Crystal Structure of Human p38alpha complexed with PH-797804

The structure was published by Xing, L., Shieh, H.S., Selness, S.R., et al., Broadus, R.M., Walden, Z., and Monahan, J.B., in 2009 in a paper entitled "Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 336 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) ATP bindingsearch MAP kinase activitysearch protein bindingsearch kinase activitysearch nucleotide bindingsearch protein serine/threonine kinase activitysearch protein kinase activitysearch transferase activitysearch NFAT protein bindingsearch transferase activity, transferring phosphorus-containing groupssearch MAP kinase kinase activitysearch protein phosphorylationsearch cellular response to vascular endothelial growth factor stimulussearch toll-like receptor 2 signaling pathwaysearch positive regulation of reactive oxygen species metabolic processsearch response to lipopolysaccharidesearch chondrocyte differentiationsearch positive regulation of muscle cell differentiationsearch toll-like receptor 4 signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch vascular endothelial growth factor receptor signaling pathwaysearch peptidyl-serine phosphorylationsearch regulation of transcription, DNA-templatedsearch osteoclast differentiationsearch MyD88-dependent toll-like receptor signaling pathwaysearch positive regulation of myoblast fusionsearch transcription, DNA-templatedsearch p38MAPK cascadesearch toll-like receptor TLR1:TLR2 signaling pathwaysearch stress-activated MAPK cascadesearch myoblast differentiation involved in skeletal muscle regenerationsearch Ras protein signal transductionsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch cell surface receptor signaling pathwaysearch regulation of transcription from RNA polymerase II promotersearch positive regulation of blood vessel endothelial cell migrationsearch positive regulation of brown fat cell differentiationsearch positive regulation of myotube differentiationsearch chemotaxissearch activation of MAPK activitysearch toll-like receptor 5 signaling pathwaysearch angiogenesissearch movement of cell or subcellular componentsearch neurotrophin TRK receptor signaling pathwaysearch cell morphogenesissearch platelet activationsearch innate immune responsesearch signal transductionsearch lipopolysaccharide-mediated signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch organelle organizationsearch cellular response to DNA damage stimulussearch apoptotic processsearch cellular response to lipopolysaccharidesearch fatty acid oxidationsearch response to muramyl dipeptidesearch 3'-UTR-mediated mRNA stabilizationsearch gene expressionsearch muscle cell differentiationsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch positive regulation of erythrocyte differentiationsearch toll-like receptor 9 signaling pathwaysearch glucose metabolic processsearch mitochondrion organizationsearch regulation of sequence-specific DNA binding transcription factor activitysearch blood coagulationsearch negative regulation of canonical Wnt signaling pathwaysearch phosphorylationsearch cartilage condensationsearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of myoblast differentiationsearch toll-like receptor 3 signaling pathwaysearch positive regulation of protein import into nucleussearch DNA damage checkpointsearch signal transduction in response to DNA damagesearch cellular response to ionizing radiationsearch toll-like receptor signaling pathwaysearch stress-induced premature senescencesearch skeletal muscle tissue developmentsearch toll-like receptor 10 signaling pathwaysearch striated muscle cell differentiationsearch intracellular signal transductionsearch nucleoplasmsearch mitochondrionsearch cytosolsearch nucleussearch spindle polesearch cellsearch cytoplasmsearch extracellular vesicular exosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch