3hlj Summary


Crystal structure of human carbonic anhydrase isozyme II with 3-methylthiobenzimidazo[1,2-c][1,2,3]thiadiazol-7-sulfonamide

The structure was published by Baranauskiene, L., Hilvo, M., Matuliene, J., et al., Supuran, C.T., Grazulis, S., and Matulis, D., in 2010 in a paper entitled "Inhibition and binding studies of carbonic anhydrase isozymes I, II and IX with benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulphonamides" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.44 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P00918) cytoplasmsearch extracellular vesicular exosomesearch basolateral plasma membranesearch cytosolsearch apical part of cellsearch plasma membranesearch microvillussearch membranesearch axonsearch myelin sheathsearch extracellular spacesearch metal ion bindingsearch lyase activitysearch protein bindingsearch carbonate dehydratase activitysearch zinc ion bindingsearch positive regulation of osteoclast differentiationsearch odontogenesis of dentin-containing toothsearch response to zinc ionsearch morphogenesis of an epitheliumsearch secretionsearch response to organic substancesearch bicarbonate transportsearch one-carbon metabolic processsearch response to pHsearch regulation of anion transportsearch positive regulation of cellular pH reductionsearch positive regulation of dipeptide transmembrane transportsearch response to estrogensearch regulation of intracellular pHsearch regulation of chloride transportsearch kidney developmentsearch angiotensin-activated signaling pathwaysearch positive regulation of synaptic transmission, GABAergicsearch positive regulation of bone resorptionsearch response to steroid hormonesearch small molecule metabolic processsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch