3hku Summary


Human carbonic anhydrase II in complex with topiramate

The structure was published by Lopez, M., Paul, B., Hofmann, A., et al., Vullo, D., Supuran, C.T., and Poulsen, S.-A., in 2009 in a paper entitled "S-Glycosyl Primary Sulfonamides-A New Structural Class for Selective Inhibition of Cancer-Associated Carbonic Anhydrases" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) carbonate dehydratase activitysearch metal ion bindingsearch protein bindingsearch lyase activitysearch zinc ion bindingsearch extracellular spacesearch plasma membranesearch cytoplasmsearch apical part of cellsearch extracellular vesicular exosomesearch axonsearch membranesearch basolateral plasma membranesearch cytosolsearch myelin sheathsearch microvillussearch kidney developmentsearch secretionsearch regulation of anion transportsearch angiotensin-activated signaling pathwaysearch response to organic substancesearch positive regulation of cellular pH reductionsearch morphogenesis of an epitheliumsearch positive regulation of dipeptide transmembrane transportsearch positive regulation of synaptic transmission, GABAergicsearch response to zinc ionsearch regulation of intracellular pHsearch small molecule metabolic processsearch response to steroid hormonesearch odontogenesis of dentin-containing toothsearch one-carbon metabolic processsearch response to pHsearch bicarbonate transportsearch positive regulation of osteoclast differentiationsearch positive regulation of bone resorptionsearch regulation of chloride transportsearch response to estrogensearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch