3hkn Summary


Human carbonic anhydrase II in complex with (2,3,4,6-Tetra-O-acetyl-beta-D-galactopyranosyl) -(1-4)-1,2,3,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosylsulfonamide

The structure was published by Lopez, M., Paul, B., Hofmann, A., et al., Vullo, D., Supuran, C.T., and Poulsen, S.A., in 2009 in a paper entitled "S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) zinc ion bindingsearch protein bindingsearch carbonate dehydratase activitysearch metal ion bindingsearch lyase activitysearch positive regulation of dipeptide transmembrane transportsearch positive regulation of cellular pH reductionsearch positive regulation of bone resorptionsearch one-carbon metabolic processsearch response to steroid hormonesearch bicarbonate transportsearch angiotensin-activated signaling pathwaysearch regulation of intracellular pHsearch regulation of anion transportsearch positive regulation of osteoclast differentiationsearch response to pHsearch secretionsearch positive regulation of synaptic transmission, GABAergicsearch morphogenesis of an epitheliumsearch small molecule metabolic processsearch response to organic substancesearch regulation of chloride transportsearch odontogenesis of dentin-containing toothsearch response to estrogensearch kidney developmentsearch response to zinc ionsearch extracellular vesicular exosomesearch cytoplasmsearch cytosolsearch apical part of cellsearch plasma membranesearch membranesearch basolateral plasma membranesearch extracellular spacesearch myelin sheathsearch axonsearch microvillussearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch