3hhi Summary

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Crystal Structure of Cathepsin B from T. brucei in complex with CA074

The structure was published by Kerr, I.D., Wu, P., Marion-Tsukamaki, R., Mackey, Z.B., and Brinen, L.S., in 2010 in a paper entitled "Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Cathepsin B-like cysteine protease.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cathepsin B-like cysteine protease Q6R7Z5 (23-340) (Q6R7Z5_9TRYP)search Trypanosoma bruceisearch 93% 325 80%
B Cathepsin B-like cysteine protease Q6R7Z5 (23-340) (Q6R7Z5_9TRYP)search Trypanosoma bruceisearch 93% 325 80%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q6R7Z5 (23 - 340) Cathepsin B-like cysteine protease Trypanosoma brucei

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (Q6R7Z5) Cysteine proteinasessearch PF00112: Papain family cysteine proteasesearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (Q6R7Z5) proteolysissearch peptidase activitysearch cysteine-type peptidase activitysearch

Chain InterPro annotation
A, B Cysteine peptidase, cysteine active sitesearch Peptidase C1A, papain C-terminalsearch Peptidase C1Asearch Peptidase C1A, cathepsin Bsearch Cysteine peptidase, histidine active sitesearch