3heg Summary


P38 in complex with Sorafenib

The structure was published by Namboodiri, H.V., Bukhtiyarova, M., Ramcharan, J., Karpusas, M., Lee, Y., and Springman, E.B., in 2010 in a paper entitled "Analysis of imatinib and sorafenib binding to p38alpha compared with c-Abl and b-Raf provides structural insights for understanding the selectivity of inhibitors targeting the DFG-out form of protein kinases." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 348 residues which is 97% of the natural sequence. Out of 348 residues 331 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (5-352) (MK14_HUMAN)search Homo sapienssearch 97% 348 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (5 - 352) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (Q16539) response to lipopolysaccharidesearch toll-like receptor signaling pathwaysearch regulation of transcription, DNA-templatedsearch peptidyl-serine phosphorylationsearch toll-like receptor 10 signaling pathwaysearch positive regulation of myoblast fusionsearch positive regulation of myoblast differentiationsearch toll-like receptor 5 signaling pathwaysearch positive regulation of erythrocyte differentiationsearch positive regulation of muscle cell differentiationsearch p38MAPK cascadesearch 3'-UTR-mediated mRNA stabilizationsearch MyD88-dependent toll-like receptor signaling pathwaysearch cell morphogenesissearch toll-like receptor 9 signaling pathwaysearch angiogenesissearch protein phosphorylationsearch positive regulation of protein import into nucleussearch regulation of transcription from RNA polymerase II promotersearch MyD88-independent toll-like receptor signaling pathwaysearch Ras protein signal transductionsearch muscle cell differentiationsearch myoblast differentiation involved in skeletal muscle regenerationsearch stress-activated MAPK cascadesearch chondrocyte differentiationsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch stress-induced premature senescencesearch cell surface receptor signaling pathwaysearch innate immune responsesearch positive regulation of blood vessel endothelial cell migrationsearch cellular response to ionizing radiationsearch signal transductionsearch fatty acid oxidationsearch toll-like receptor 4 signaling pathwaysearch osteoclast differentiationsearch TRIF-dependent toll-like receptor signaling pathwaysearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch glucose metabolic processsearch platelet activationsearch regulation of sequence-specific DNA binding transcription factor activitysearch toll-like receptor 3 signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch cellular response to DNA damage stimulussearch cellular component movementsearch blood coagulationsearch gene expressionsearch cartilage condensationsearch positive regulation of reactive oxygen species metabolic processsearch toll-like receptor 2 signaling pathwaysearch phosphorylationsearch DNA damage checkpointsearch response to stresssearch response to muramyl dipeptidesearch intracellular signal transductionsearch cellular response to lipopolysaccharidesearch skeletal muscle tissue developmentsearch transcription, DNA-templatedsearch neurotrophin TRK receptor signaling pathwaysearch lipopolysaccharide-mediated signaling pathwaysearch striated muscle cell differentiationsearch RNA metabolic processsearch positive regulation of myotube differentiationsearch negative regulation of canonical Wnt signaling pathwaysearch mRNA metabolic processsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch cellular response to vascular endothelial growth factor stimulussearch vascular endothelial growth factor receptor signaling pathwaysearch chemotaxissearch activation of MAPK activitysearch apoptotic processsearch signal transduction in response to DNA damagesearch nucleoplasmsearch spindle polesearch cytoplasmsearch cytosolsearch nucleussearch cellsearch mitochondrionsearch extracellular vesicular exosomesearch kinase activitysearch protein bindingsearch protein serine/threonine kinase activitysearch NFAT protein bindingsearch MAP kinase activitysearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch MAP kinase kinase activitysearch nucleotide bindingsearch transferase activitysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch