3hec Summary


P38 in complex with Imatinib

The structure was published by Namboodiri, H.V., Bukhtiyarova, M., Ramcharan, J., Karpusas, M., Lee, Y., and Springman, E.B., in 2010 in a paper entitled "Analysis of imatinib and sorafenib binding to p38alpha compared with c-Abl and b-Raf provides structural insights for understanding the selectivity of inhibitors targeting the DFG-out form of protein kinases." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 348 residues which is 97% of the natural sequence. Out of 348 residues 328 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (5-352) (MK14_HUMAN)search Homo sapienssearch 97% 348 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (5 - 352) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (Q16539) regulation of sequence-specific DNA binding transcription factor activitysearch osteoclast differentiationsearch peptidyl-serine phosphorylationsearch TRIF-dependent toll-like receptor signaling pathwaysearch regulation of transcription from RNA polymerase II promotersearch toll-like receptor 4 signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch toll-like receptor 5 signaling pathwaysearch vascular endothelial growth factor receptor signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch stress-induced premature senescencesearch protein phosphorylationsearch cellular response to DNA damage stimulussearch gene expressionsearch positive regulation of myoblast fusionsearch apoptotic processsearch positive regulation of muscle cell differentiationsearch mRNA metabolic processsearch toll-like receptor 2 signaling pathwaysearch intracellular signal transductionsearch striated muscle cell differentiationsearch platelet activationsearch DNA damage checkpointsearch Ras protein signal transductionsearch cellular response to vascular endothelial growth factor stimulussearch cartilage condensationsearch cellular component movementsearch regulation of transcription, DNA-templatedsearch positive regulation of protein import into nucleussearch signal transductionsearch positive regulation of erythrocyte differentiationsearch positive regulation of reactive oxygen species metabolic processsearch positive regulation of myotube differentiationsearch positive regulation of blood vessel endothelial cell migrationsearch toll-like receptor signaling pathwaysearch lipopolysaccharide-mediated signaling pathwaysearch signal transduction in response to DNA damagesearch chemotaxissearch response to muramyl dipeptidesearch activation of MAPK activitysearch cell surface receptor signaling pathwaysearch muscle cell differentiationsearch transcription, DNA-templatedsearch p38MAPK cascadesearch response to lipopolysaccharidesearch positive regulation of transcription from RNA polymerase II promotersearch skeletal muscle tissue developmentsearch fatty acid oxidationsearch MyD88-dependent toll-like receptor signaling pathwaysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch 3'-UTR-mediated mRNA stabilizationsearch stress-activated MAPK cascadesearch negative regulation of canonical Wnt signaling pathwaysearch chondrocyte differentiationsearch angiogenesissearch toll-like receptor 3 signaling pathwaysearch blood coagulationsearch toll-like receptor 9 signaling pathwaysearch cellular response to ionizing radiationsearch positive regulation of myoblast differentiationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch neurotrophin TRK receptor signaling pathwaysearch response to stresssearch innate immune responsesearch MAPK cascadesearch cellular response to lipopolysaccharidesearch glucose metabolic processsearch cell morphogenesissearch phosphorylationsearch RNA metabolic processsearch nucleoplasmsearch cytosolsearch mitochondrionsearch cytoplasmsearch nucleussearch spindle polesearch cellsearch extracellular vesicular exosomesearch kinase activitysearch protein bindingsearch NFAT protein bindingsearch MAP kinase activitysearch nucleotide bindingsearch protein serine/threonine kinase activitysearch MAP kinase kinase activitysearch protein kinase activitysearch transferase activitysearch ATP bindingsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch