3hdm Summary

pdbe.org/3hdm
spacer

Crystal structure of serum and glucocorticoid-regulated kinase 1 in complex with compound 1

The structure was published by Hammond, M., Washburn, D.G., Hoang, H.T., et al., Laping, N.J., Schnackenberg, C.G., and Thompson, S.K., in 2009 in a paper entitled "Design and synthesis of orally bioavailable serum and glucocorticoid-regulated kinase 1 (SGK1) inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Serine/threonine-protein kinase Sgk1. This molecule has the UniProt identifier O00141 (SGK1_HUMAN)search. The sample contained 373 residues which is < 90% of the natural sequence. Out of 373 residues 280 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Serine/threonine-protein kinase Sgk1 O00141 (60-431) (SGK1_HUMAN)search Homo sapienssearch < 90% 373 76%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O00141 (60 - 431) Serine/threonine-protein kinase Sgk1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch, Protein kinase C terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (O00141) protein serine/threonine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Protein kinase, C-terminalsearch