3hd6 Citations

Function of human Rh based on structure of RhCG at 2.1 A.

Proc Natl Acad Sci U S A 107 9638-43 (2010)
Cited: 127 times
EuropePMC logo PMID: 20457942

Abstract

In humans, NH(3) transport across cell membranes is facilitated by the Rh (rhesus) family of proteins. Human Rh C glycoprotein (RhCG) forms a trimeric complex that plays an essential role in ammonia excretion and renal pH regulation. The X-ray crystallographic structure of human RhCG, determined at 2.1 A resolution, reveals the mechanism of ammonia transport. Each monomer contains 12 transmembrane helices, one more than in the bacterial homologs. Reconstituted into proteoliposomes, RhCG conducts NH(3) to raise internal pH. Models of the erythrocyte Rh complex based on our RhCG structure suggest that the erythrocytic Rh complex is composed of stochastically assembled heterotrimers of RhAG, RhD, and RhCE.

Reviews - 3hd6 mentioned but not cited (3)

Articles - 3hd6 mentioned but not cited (15)

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Reviews citing this publication (30)

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Articles citing this publication (79)

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