3hcm Summary


Crystal structure of human S100B in complex with S45

The structure was published by Agamennone, M., Cesari, L., Lalli, D., et al., Turano, P., Mangani, S., and Padova, A., in 2010 in a paper entitled "Fragmenting the S100B-p53 Interaction: Combined Virtual/Biophysical Screening Approaches to Identify Ligands" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Protein S100-B.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein S100-B P04271 (1-92) (S100B_HUMAN)search Homo sapienssearch 99% 92 98%
B Protein S100-B P04271 (1-92) (S100B_HUMAN)search Homo sapienssearch 99% 92 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04271 (1 - 92) Protein S100-B Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P04271) EF-handsearch PF01023: S-100/ICaBP type calcium binding domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P04271) astrocyte differentiationsearch learning or memorysearch response to methylmercurysearch negative regulation of skeletal muscle cell differentiationsearch axonogenesissearch cell proliferationsearch positive regulation of apoptotic processsearch positive regulation of synaptic transmissionsearch regulation of neuronal synaptic plasticitysearch cellular response to hypoxiasearch memorysearch long-term synaptic potentiationsearch response to glucocorticoidsearch positive regulation of I-kappaB kinase/NF-kappaB signalingsearch central nervous system developmentsearch innate immune responsesearch regulation of cell shapesearch positive regulation of cell proliferationsearch calcium ion bindingsearch tau protein bindingsearch protein bindingsearch identical protein bindingsearch S100 protein bindingsearch protein homodimerization activitysearch RAGE receptor bindingsearch zinc ion bindingsearch metal ion bindingsearch receptor bindingsearch calcium-dependent protein bindingsearch cytoplasmsearch extracellular regionsearch rufflesearch perinuclear region of cytoplasmsearch nucleussearch intracellular membrane-bounded organellesearch extracellular spacesearch neuronal cell bodysearch

Chain InterPro annotation
A, B S100/Calbindin-D9k, conserved sitesearch EF-hand domainsearch EF-hand domain pairsearch S100/CaBP-9k-type, calcium binding, subdomainsearch EF-Hand 1, calcium-binding sitesearch Protein S100-Bsearch