3ha6 Summary


Crystal structure of aurora A in complex with TPX2 and compound 10

The structure was published by Clark, M.A., Acharya, R.A., Arico-Muendel, C.C., et al., Yao, G., Zhao, B., and Morgan, B.A., in 2009 in a paper entitled "Design, synthesis and selection of DNA-encoded small-molecule libraries." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.36 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Serine/threonine-protein kinase 6 and Targeting protein for Xklp2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Serine/threonine-protein kinase 6 O14965 (125-391) (AURKA_HUMAN)search Homo sapienssearch < 90% 268 98%
B Targeting protein for Xklp2 Q9ULW0 (1-43) (TPX2_HUMAN)search Homo sapienssearch < 90% 44 81%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
O14965 (125 - 391) Serine/threonine-protein kinase 6 Homo sapiens
Q9ULW0 (1 - 43) Targeting protein for Xklp2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch
B Aurora-A bindingsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (O14965) protein kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch
B (Q9ULW0) mitotic nuclear divisionsearch microtubulesearch spindlesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B TPX2search Aurora-A bindingsearch