3h9r Summary


Crystal structure of the kinase domain of type I activin receptor (ACVR1) in complex with FKBP12 and dorsomorphin

The structure was published by Chaikuad, A., Alfano, I., Kerr, G., et al., Knapp, S., Knaus, P., and Bullock, A.N., in 2012 in a paper entitled "Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.35 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Activin receptor type-1 and Peptidyl-prolyl cis-trans isomerase FKBP1A.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Activin receptor type-1 Q04771 (172-499) (ACVR1_HUMAN)search Homo sapienssearch < 90% 330 94%
B Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 (1-108) (FKB1A_HUMAN)search Homo sapienssearch 99% 109 98%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q04771 (172 - 499) Activin receptor type-1 Homo sapiens
P62942 (1 - 108) Peptidyl-prolyl cis-trans isomerase FKBP1A Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch, Transforming growth factor beta type I GS-motifsearch
B (P62942) PF00254: FKBP-type peptidyl-prolyl cis-trans isomerasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (Q04771) protein phosphorylationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch membranesearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein serine/threonine kinase activitysearch protein kinase activitysearch receptor signaling protein serine/threonine kinase activitysearch transmembrane receptor protein serine/threonine kinase activitysearch
B (P62942) calcium ion transmembrane transportsearch negative regulation of release of sequestered calcium ion into cytosolsearch T cell activationsearch amyloid fibril formationsearch protein maturation by protein foldingsearch regulation of protein localizationsearch protein peptidyl-prolyl isomerizationsearch heart trabecula formationsearch protein foldingsearch positive regulation of protein ubiquitinationsearch chaperone-mediated protein foldingsearch heart morphogenesissearch regulation of immune responsesearch negative regulation of ryanodine-sensitive calcium-release channel activitysearch SMAD protein complex assemblysearch ventricular cardiac muscle tissue morphogenesissearch regulation of ryanodine-sensitive calcium-release channel activitysearch transforming growth factor beta receptor signaling pathwaysearch negative regulation of protein phosphatase type 2B activitysearch protein refoldingsearch extracellular fibril organizationsearch positive regulation of I-kappaB kinase/NF-kappaB signalingsearch regulation of activin receptor signaling pathwaysearch 'de novo' protein foldingsearch positive regulation of protein bindingsearch regulation of amyloid precursor protein catabolic processsearch cytosolsearch cytoplasmsearch extracellular vesicular exosomesearch endoplasmic reticulum membranesearch Z discsearch membranesearch terminal cisternasearch macrolide bindingsearch FK506 bindingsearch transforming growth factor beta-activated receptor activitysearch ion channel bindingsearch protein bindingsearch peptidyl-prolyl cis-trans isomerase activitysearch calcium channel inhibitor activitysearch transforming growth factor beta receptor bindingsearch type I transforming growth factor beta receptor bindingsearch activin bindingsearch signal transducer activitysearch SMAD bindingsearch ryanodine-sensitive calcium-release channel activitysearch isomerase activitysearch

Chain InterPro annotation
A Ser/Thr protein kinase, TGFB receptorsearch Protein kinase domainsearch TGF beta receptor, GS motifsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B Peptidyl-prolyl cis-trans isomerase, FKBP-type, domainsearch Peptidyl-prolyl cis-trans isomerase, FKBP-typesearch