3h8f Summary

pdbe.org/3h8f
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High pH native structure of leucine aminopeptidase from Pseudomonas putida

The structure was published by Kale, A., Pijning, T., Sonke, T., Dijkstra, B.W., and Thunnissen, A.M., in 2010 in a paper entitled "Crystal structure of the leucine aminopeptidase from Pseudomonas putida reveals the molecular basis for its enantioselectivity and broad substrate specificity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Cytosol aminopeptidase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homohexamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cytosol aminopeptidase O86436 (1-497) (AMPA_PSEPU)search Pseudomonas putidasearch 100% 497 100%
B Cytosol aminopeptidase O86436 (1-497) (AMPA_PSEPU)search Pseudomonas putidasearch 100% 497 100%
C Cytosol aminopeptidase O86436 (1-497) (AMPA_PSEPU)search Pseudomonas putidasearch 100% 497 100%
D Cytosol aminopeptidase O86436 (1-497) (AMPA_PSEPU)search Pseudomonas putidasearch 100% 497 100%
E Cytosol aminopeptidase O86436 (1-497) (AMPA_PSEPU)search Pseudomonas putidasearch 100% 497 100%
F Cytosol aminopeptidase O86436 (1-497) (AMPA_PSEPU)search Pseudomonas putidasearch 100% 497 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O86436 (1 - 497) Cytosol aminopeptidase Pseudomonas putida

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F (O86436) Leucine Aminopeptidase, subunit E, domain 1search, Zn peptidasessearch PF00883: Cytosol aminopeptidase family, catalytic domainsearch, PF02789: Cytosol aminopeptidase family, N-terminal domainsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B, C, D, E, F (O86436) intracellularsearch cytoplasmsearch aminopeptidase activitysearch metalloexopeptidase activitysearch manganese ion bindingsearch hydrolase activitysearch peptidase activitysearch metal ion bindingsearch protein metabolic processsearch proteolysissearch

Chain InterPro annotation
A, B, C, D, E, F Peptidase M17, leucyl aminopeptidase, C-terminalsearch Peptidase M17, leucyl aminopeptidase, N-terminalsearch Leucine aminopeptidase/peptidase Bsearch Peptidase M17, leucine aminopeptidasesearch