3h7d Summary

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The crystal structure of the cathepsin K Variant M5 in complex with chondroitin-4-sulfate

The structure was published by Cherney, M.M., Lecaille, F., Kienitz, M., et al., Li, Z., James, M.N., and Bromme, D., in 2011 in a paper entitled "Structure-activity analysis of cathepsin K/chondroitin 4-sulfate interactions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.242 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Cathepsin K.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cathepsin K P43235 (115-329) (CATK_HUMAN)search Homo sapienssearch 100% 215 100%
E Cathepsin K P43235 (115-329) (CATK_HUMAN)search Homo sapienssearch 100% 215 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P43235 (115 - 329) Cathepsin K Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, E (P43235) Cysteine proteinasessearch PF00112: Papain family cysteine proteasesearch

Chain ID Biological process (GO) Molecular function (GO)
A, E (P43235) proteolysissearch cysteine-type peptidase activitysearch

Chain InterPro annotation
A, E Cysteine peptidase, cysteine active sitesearch Peptidase C1A, papain C-terminalsearch Peptidase C1Asearch Peptidase C1A, cathepsin Ksearch Cysteine peptidase, histidine active sitesearch Cysteine peptidase, asparagine active sitesearch