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Crystal structure of Streptococcus pneumoniae D39 neuraminidase A precursor (NanA) in complex with DANA

X-ray diffraction
1.7Å resolution
PDB entry 3h73 coloured by chain, front view.
PDB entry 3h73 coloured by chain, side view.
PDB entry 3h73 coloured by chain, top view.
Source organism: Streptococcus pneumoniae R6
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Sialidase A
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Multimeric state: monomeric
Accessible surface area: 18765.46 Å2
Buried surface area: 623.25 Å2
Dissociation area: 311.62 Å2
Dissociation energy (ΔGdiss): 0.3 kcal/mol
Dissociation entropy (TΔSdiss): 3.94 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158649
Assembly 2
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Assembly Name: Sialidase A
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Multimeric state: monomeric
Accessible surface area: 18983.05 Å2
Buried surface area: 621.31 Å2
Dissociation area: 310.66 Å2
Dissociation energy (ΔGdiss): 0.51 kcal/mol
Dissociation entropy (TΔSdiss): 3.93 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158649

Macromolecules

Sialidase A
Chains: A, B
Length: 477 amino acids
Theoretical weight: 53.57 KDa
Source organism: Streptococcus pneumoniae R6
Expression system: Escherichia coli
UniProt:
  • Canonical: P62576 (Residues: 317-793; Coverage: 49%)
Gene names: nanA, spr1536
Pfam: BNR/Asp-box repeat
InterPro:
CATH:
Sialidase A in PDB entry 3h73, assembly 1, front view.
Sialidase A in PDB entry 3h73, assembly 1, side view.
Sialidase A in PDB entry 3h73, assembly 1, top view.
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