Function and Biology Details
Reaction catalysed:
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-|-(Gly/Ser/Ala)
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-127506 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
CASP8 and FADD-like apoptosis regulator subunit p43
Molecule details ›
Chain: A
Length: 272 amino acids
Theoretical weight: 31.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Caspase domain
Structure domains: Rossmann fold
Length: 272 amino acids
Theoretical weight: 31.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
O15519 (Residues: 209-480; Coverage: 57%)
Sequence domains: Caspase domain
Structure domains: Rossmann fold
Caspase-8 subunit p18
Molecule details ›
Chain: B
Length: 271 amino acids
Theoretical weight: 31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Caspase domain
Structure domains: Rossmann fold
Length: 271 amino acids
Theoretical weight: 31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q14790 (Residues: 217-479; Coverage: 55%)
Sequence domains: Caspase domain
Structure domains: Rossmann fold
