3h10 Summary

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Aurora A inhibitor complex

The structure was published by Aliagas-Martin, I., Burdick, D., Corson, L., et al., Zhang, B., Zhu, B.Y., and Cochran, A.G., in 2009 in a paper entitled "A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Serine/threonine-protein kinase 6.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Serine/threonine-protein kinase 6 O14965 (124-391) (AURKA_HUMAN)search Homo sapienssearch < 90% 268 100%
B Serine/threonine-protein kinase 6 O14965 (124-391) (AURKA_HUMAN)search Homo sapienssearch < 90% 268 100%
D Serine/threonine-protein kinase 6 O14965 (124-391) (AURKA_HUMAN)search Homo sapienssearch < 90% 268 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O14965 (124 - 391) Serine/threonine-protein kinase 6 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, D Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B, D (O14965) ATP bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A, B, D Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch