› 3h0y

X-ray diffraction
2.5Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127232 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aurora kinase A Chain: A
Molecule details ›
Chain: A
Length: 268 amino acids
Theoretical weight: 31.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14965 (Residues: 124-391; Coverage: 67%)
Gene names: AIK, AIRK1, ARK1, AURA, AURKA, AYK1, BTAK, IAK1, STK15, STK6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 48B 1 x 48B
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P6122
Unit cell:
a: 81.377Å b: 81.377Å c: 170.892Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.216 0.208 0.285
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Aurora-A kinase inhibitor scaffolds and binding modes.
Yan et al. (2011)
1 more

2 mentions without citation

Aurora kinase inhibitors: progress towards the clinic.
Kollareddy et al. (2012)
1 more