Crystal Structure of Peroxisome Proliferator-Activated Receptor Gamma (PPARg) and Retinoic Acid Receptor Alpha (RXRa) in Complex with 9-cis Retinoic Acid, Co-activator Peptide, and a Partial Agonist
The structure was published by Connors, R.V., Wang, Z., Harrison, M., et al., Siegler, K., Li, Y., and Coward, P., in 2009 in a paper entitled "Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2009.
The experimental data on which the structure is based was also deposited.
This PDB entry contains a complex of 3 biomacromolecules, namely Retinoic acid receptor RXR-alpha, Peroxisome proliferator-activated receptor gamma, and Nuclear receptor coactivator 1, Co-activator Peptide.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule most likely forms heterotetramers.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 3 unique UniProt proteins: