3h0a Summary

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Crystal Structure of Peroxisome Proliferator-Activated Receptor Gamma (PPARg) and Retinoic Acid Receptor Alpha (RXRa) in Complex with 9-cis Retinoic Acid, Co-activator Peptide, and a Partial Agonist

The structure was published by Connors, R.V., Wang, Z., Harrison, M., et al., Siegler, K., Li, Y., and Coward, P., in 2009 in a paper entitled "Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Retinoic acid receptor RXR-alpha, Peroxisome proliferator-activated receptor gamma, and Nuclear receptor coactivator 1, Co-activator Peptide.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Retinoic acid receptor RXR-alpha P19793 (228-455) (RXRA_HUMAN)search Homo sapienssearch 98% 228 92%
D Peroxisome proliferator-activated receptor gamma P37231 (234-505) (PPARG_HUMAN)search Homo sapienssearch < 90% 272 97%
B Nuclear receptor coactivator 1, Co-activator Peptide Q15788 (629-640) (NCOA1_HUMAN)search Homo sapienssearch < 90% 12 100%
E Nuclear receptor coactivator 1, Co-activator Peptide Q15788 (629-640) (NCOA1_HUMAN)search Homo sapienssearch < 90% 12 100%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P19793 (228 - 455) Retinoic acid receptor RXR-alpha Homo sapiens
P37231 (234 - 505) Peroxisome proliferator-activated receptor gamma Homo sapiens
Q15788 (629 - 640) Nuclear receptor coactivator 1, Co-activator Peptide Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P19793) Retinoid X Receptorsearch PF00104: Ligand-binding domain of nuclear hormone receptorsearch
D Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
B, E Steroid receptor coactivatorsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P19793) regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch zinc ion bindingsearch steroid hormone receptor activitysearch DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch nucleussearch
D (P37231) regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch DNA bindingsearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch nucleussearch
B, E (Q15788) regulation of transcription, DNA-templatedsearch histone acetyltransferase activitysearch nucleussearch

Chain InterPro annotation
A Retinoid X receptor/HNF4search Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
D Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Peroxisome proliferator-activated receptorsearch Nuclear hormone receptor, ligand-bindingsearch
B, E Nuclear receptor coactivator Src-1search