3gz0 Summary


Apo-human carbonic anhydrase II revisited: Implications of the loss of a metal in protein structure, stability and solvent network

The structure was published by Avvaru, B.S., Busby, S.A., Chalmers, M.J., et al., Agbandje-McKenna, M., Silverman, D.N., and McKenna, R., in 2009 in a paper entitled "Apo-Human Carbonic Anhydrase II Revisited: Implications of the Loss of a Metal in Protein Structure, Stability, and Solvent Network ." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.26 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00918) kidney developmentsearch morphogenesis of an epitheliumsearch one-carbon metabolic processsearch response to pHsearch response to organic substancesearch response to zinc ionsearch bicarbonate transportsearch positive regulation of synaptic transmission, GABAergicsearch positive regulation of cellular pH reductionsearch angiotensin-activated signaling pathwaysearch odontogenesis of dentin-containing toothsearch response to estrogensearch regulation of anion transportsearch small molecule metabolic processsearch positive regulation of osteoclast differentiationsearch positive regulation of bone resorptionsearch secretionsearch response to steroid hormonesearch regulation of intracellular pHsearch cellular response to fluid shear stresssearch positive regulation of dipeptide transmembrane transportsearch regulation of chloride transportsearch carbonate dehydratase activitysearch protein bindingsearch zinc ion bindingsearch lyase activitysearch metal ion bindingsearch extracellular spacesearch cytoplasmsearch cytosolsearch plasma membranesearch microvillussearch membranesearch basolateral plasma membranesearch axonsearch myelin sheathsearch apical part of cellsearch extracellular vesicular exosomesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch