EC 3.2.1.46: Galactosylceramidase
Reaction catalysed:
D-galactosyl-N-acylsphingosine + H(2)O = D-galactose + N-acylsphingosine
Systematic name:
D-galactosyl-N-acylsphingosine galactohydrolase
Alternative Name(s):
- Beta-galactocerebrosidase
- Beta-galactosylceramidase
- Ceramide galactosidase
- Cerebroside beta-galactosidase
- Cerebroside galactosidase
- Galactocerebrosidase
- Galactocerebroside beta-galactosidase
- Galactocerebroside galactosidase
- Galactocerebroside-beta-D-galactosidase
- Galactocerebroside.beta-galactosidase
- Galactosylceramidase I
- Galactosylceramide beta-galactosidase
- Galactosylceramide.beta-galactosidase
- Galactosylcerebrosidase
- Galcerase
- Lactosylceramidase
- Lactosylceramidase I
EC 3.2.1.45: Glucosylceramidase
Reaction catalysed:
D-glucosyl-N-acylsphingosine + H(2)O = D-glucose + N-acylsphingosine
Systematic name:
D-glucosyl-N-acylsphingosine glucohydrolase
Alternative Name(s):
- Acid beta-glucosidase
- Beta-D-glucocerebrosidase
- Beta-glucocerebrosidase
- Beta-glucosylceramidase
- Ceramide glucosidase
- GlcCer-beta-glucosidase
- Glucocerebrosidase
- Glucosphingosine glucosylhydrolase
- Glucosylcerebrosidase
- Glucosylsphingosine beta-D-glucosidase
- Glucosylsphingosine beta-glucosidase
- Psychosine hydrolase
GO terms
Biochemical function:
- steryl-beta-glucosidase activity
- glucosyltransferase activity
- hydrolase activity, acting on glycosyl bonds
- hydrolase activity
- glycosyltransferase activity
- beta-glucosidase activity
- protein binding
- scavenger receptor binding
- signaling receptor binding
- glucosylceramidase activity
- galactosylceramidase activity
Biological process:
- regulation of lysosomal protein catabolic process
- autophagosome organization
- positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
- positive regulation of neuronal action potential
- positive regulation of protein lipidation
- positive regulation of proteolysis involved in protein catabolic process
- beta-glucoside catabolic process
- skin epidermis development
- response to thyroid hormone
- lymphocyte migration
- response to dexamethasone
- hematopoietic stem cell proliferation
- cellular response to tumor necrosis factor
- motor behavior
- microglial cell proliferation
- establishment of skin barrier
- neuron apoptotic process
- negative regulation of protein metabolic process
- regulation of protein metabolic process
- neuromuscular process
- nervous system process
- negative regulation of inflammatory response
- homeostasis of number of cells
- brain morphogenesis
- cell maturation
- ceramide biosynthetic process
- sphingosine biosynthetic process
- response to estrogen
- negative regulation of neuron apoptotic process
- negative regulation of MAP kinase activity
- positive regulation of protein-containing complex disassembly
- proteasome-mediated ubiquitin-dependent protein catabolic process
- regulation of membrane potential
- positive regulation of protein dephosphorylation
- response to testosterone
- T cell differentiation in thymus
- negative regulation of interleukin-6 production
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- regulation of TOR signaling
- negative regulation of protein-containing complex assembly
- neuron projection development
- lipid glycosylation
- termination of signal transduction
- respiratory electron transport chain
- pyramidal neuron differentiation
- cerebellar Purkinje cell layer formation
- lipid storage
- antigen processing and presentation
- regulation of macroautophagy
- microglia differentiation
- response to pH
- cellular response to starvation
- determination of adult lifespan
- cholesterol metabolic process
- central nervous system development
- lysosome organization
- mitochondrion organization
- autophagy
- glucosylceramide catabolic process
- glucosylceramide metabolic process
- sphingolipid metabolic process
Protein families (Pfam)
InterPro annotations
CATH domains
