› 3gql

X-ray diffraction
2.8Å resolution

Crystal Structure of activated receptor tyrosine kinase in complex with substrates

Released:
DOI: 10.2210/pdb3gql/pdb
PDB entry 3gql coloured by chain, front view.
PDB entry 3gql coloured by chain, side view.
PDB entry 3gql coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site.
Bae JH, Lew ED, Yuzawa S, Tomé F, Lax I, Schlessinger J
Cell 138 514-24 (2009)
PMID: 19665973

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-145801 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor receptor 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 326 amino acids
Theoretical weight: 37.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11362 (Residues: 458-774; Coverage: 40%)
Gene names: BFGFR, CEK, FGFBR, FGFR1, FLG, FLT2, HBGFR
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand GQL 3 x GQL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: C2
Unit cell:
a: 194.168Å b: 78.265Å c: 98.458Å
α: 90° β: 110.55° γ: 90°
R-values:
R R work R free
0.252 0.252 0.289
Expression system: Escherichia coli

Quick links

Citations

23 review citations

Cell signaling by receptor tyrosine kinases.
Lemmon et al. (2010)
22 more

7 mentions without citation

The azaindole framework in the design of kinase inhibitors.
Mérour et al. (2014)
6 more