3gp0 Summary


Crystal Structure of Human Mitogen Activated Protein Kinase 11 (p38 beta) in complex with Nilotinib

A publication describing this structure is not available. The depositing authors are Filippakopoulos, P.search; Barr, A.search; Fedorov, O.search; Keates, T.search; Soundararajan, M.search; Elkins, J.search; Salah, E.search; Burgess-Brown, N.search; Ugochukwu, E.search; Pike, A.C.W.search; Muniz, J.search; Roos, A.search; Chaikuad, A.search; von Delft, F.search; Arrowsmith, C.H.search; Edwards, A.M.search; Weigelt, J.search; Bountra, C.search; Knapp, S.search; Structural Genomics Consortium (SGC)search

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 11. This molecule has the UniProt identifier Q15759 (MK11_HUMAN)search. The sample contained 348 residues which is 95% of the natural sequence. Out of 348 residues 328 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 11 Q15759 (5-350) (MK11_HUMAN)search Homo sapienssearch 95% 348 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q15759 (5 - 350) Mitogen-activated protein kinase 11 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q15759) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q15759) protein phosphorylationsearch toll-like receptor 9 signaling pathwaysearch regulation of transcription, DNA-templatedsearch activation of MAPK activitysearch positive regulation of muscle cell differentiationsearch MyD88-dependent toll-like receptor signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch signal transductionsearch toll-like receptor signaling pathwaysearch innate immune responsesearch toll-like receptor 4 signaling pathwaysearch muscle cell differentiationsearch stress-activated MAPK cascadesearch Ras protein signal transductionsearch TRIF-dependent toll-like receptor signaling pathwaysearch mitochondrion organizationsearch toll-like receptor 10 signaling pathwaysearch intracellular signal transductionsearch toll-like receptor 2 signaling pathwaysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch phosphorylationsearch response to stresssearch MyD88-independent toll-like receptor signaling pathwaysearch toll-like receptor 5 signaling pathwaysearch gene expressionsearch vascular endothelial growth factor receptor signaling pathwaysearch neurotrophin TRK receptor signaling pathwaysearch organelle organizationsearch transcription, DNA-templatedsearch toll-like receptor 3 signaling pathwaysearch ATP bindingsearch MAP kinase activitysearch nucleotide bindingsearch kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch protein serine/threonine kinase activitysearch transferase activitysearch nucleoplasmsearch cytosolsearch cytoplasmsearch nucleussearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch