3goi Summary


Human glucokinase in complex with a synthetic activator

The structure was published by Mitsuya, M., Kamata, K., Bamba, M., et al., Nagata, Y., Eiki, J., and Nishimura, T., in 2009 in a paper entitled "Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.52 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glucokinase. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 455 residues which is 97% of the natural sequence. Out of 455 residues 448 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucokinase P35557 (16-465) (HXK4_HUMAN)search Homo sapienssearch 97% 455 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (16 - 465) Glucokinase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P35557) Hexokinase; domain 1search, Nucleotidyltransferase; domain 5search PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P35557) carbohydrate metabolic processsearch negative regulation of gluconeogenesissearch negative regulation of epinephrine secretionsearch cellular glucose homeostasissearch detection of glucosesearch glycogen biosynthetic processsearch positive regulation of glycolytic processsearch cellular response to glucose starvationsearch transmembrane transportsearch glucose homeostasissearch regulation of glycolytic processsearch endocrine pancreas developmentsearch glycolytic processsearch regulation of insulin secretionsearch cellular response to insulin stimulussearch carbohydrate phosphorylationsearch small molecule metabolic processsearch regulation of glucose transportsearch response to glucosesearch glucose 6-phosphate metabolic processsearch metabolic processsearch regulation of potassium ion transportsearch positive regulation of insulin secretionsearch positive regulation of phosphorylationsearch second-messenger-mediated signalingsearch phosphorylationsearch cellular response to leptin stimulussearch NADP metabolic processsearch calcium ion importsearch fructose 2,6-bisphosphate metabolic processsearch glucose transportsearch positive regulation of glycogen biosynthetic processsearch glucose metabolic processsearch hexose transportsearch positive regulation of cytosolic calcium ion concentrationsearch hexokinase activitysearch ATP bindingsearch protein bindingsearch phosphotransferase activity, alcohol group as acceptorsearch mannokinase activitysearch ADP bindingsearch kinase activitysearch glucose bindingsearch transferase activitysearch fructokinase activitysearch protein phosphatase bindingsearch catalytic activitysearch glucokinase activitysearch magnesium ion bindingsearch nucleotide bindingsearch nucleussearch cytosolsearch mitochondrionsearch cell cortexsearch nucleoplasmsearch cytoplasmsearch secretory granulesearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch