3gk1 Summary


X-ray structure of bovine SBi132,Ca(2+)-S100B

The structure was published by Charpentier, T.H., Wilder, P.T., Liriano, M.A., et al., MacKerell, A.D., Toth, E.A., and Weber, D.J., in 2009 in a paper entitled "Small molecules bound to unique sites in the target protein binding cleft of calcium-bound S100B as characterized by nuclear magnetic resonance and X-ray crystallography." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Protein S100-B. This molecule has the UniProt identifier P02638 (S100B_BOVIN)search. The sample contained 92 residues which is 100% of the natural sequence. Out of 92 residues 88 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein S100-B P02638 (1-92) (S100B_BOVIN)search Bos taurussearch 96% 92 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P02638 (1 - 92) Protein S100-B Bos taurus

Chain Structural classification (CATH) Sequence family (Pfam)
A (P02638) EF-handsearch PF00036: EF handsearch, PF01023: S-100/ICaBP type calcium binding domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P02638) calcium ion bindingsearch protein homodimerization activitysearch protein bindingsearch kinase inhibitor activitysearch metal ion bindingsearch calcium-dependent protein bindingsearch identical protein bindingsearch zinc ion bindingsearch S100 protein bindingsearch RAGE receptor bindingsearch tau protein bindingsearch negative regulation of phosphorylationsearch learning or memorysearch axonogenesissearch regulation of neuronal synaptic plasticitysearch positive regulation of complement activationsearch astrocyte activationsearch positive regulation of I-kappaB kinase/NF-kappaB signalingsearch regulation of translationsearch memorysearch phosphorylationsearch nucleussearch cytoplasmsearch rufflesearch intracellular membrane-bounded organellesearch perinuclear region of cytoplasmsearch neuronal cell bodysearch

Chain InterPro annotation
A S100/Calbindin-D9k, conserved sitesearch EF-hand domainsearch EF-hand domain pairsearch S100/CaBP-9k-type, calcium binding, subdomainsearch EF-Hand 1, calcium-binding sitesearch Protein S100-Bsearch