3gic Summary


Structure of thrombin mutant delta(146-149e) in the free form

The structure was published by Bah, A., Carrell, C.J., Chen, Z., Gandhi, P.S., and Di Cera, E., in 2009 in a paper entitled "Stabilization of the E* form turns thrombin into an anticoagulant." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.55 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Thrombin light chain and Thrombin heavy chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Thrombin light chain P00734 (328-363) (THRB_HUMAN)search Homo sapienssearch 93% 36 77%
B Thrombin heavy chain P00734 (364-622) (THRB_HUMAN)search Homo sapienssearch 93% 250 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00734 (328 - 363) Thrombin light chain Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00734) PF09396: Thrombin light chainsearch
B (P00734) Trypsin-like serine proteasessearch PF00089: Trypsinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00734) blood coagulationsearch proteolysissearch serine-type endopeptidase activitysearch extracellular regionsearch
B (P00734) blood coagulationsearch proteolysissearch serine-type endopeptidase activitysearch catalytic activitysearch calcium ion bindingsearch

Chain InterPro annotation
A Thrombin light chainsearch
B Peptidase S1search Peptidase S1A, chymotrypsin-typesearch Prothrombin/thrombinsearch Trypsin-like cysteine/serine peptidase domainsearch Peptidase S1, trypsin family, active sitesearch